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Patents

  1. Alkyl alpha-hydroxymethyl acrylates as reactive surfactants in emulsion polymerization; A. Joy, C. Peng; US 10,118,887; issued: Nov 6, 2018
  2.  Thermoresponsive polyesters; A. Joy, J. Swanson; US 10,106,514; issued: Oct 23, 2018
  3. Densely functionalized polymers derived from Baylis-Hillman adducts; A. Joy, C. Peng; US 9,963,540; issued: May 8, 2018
  4. Photoresponsive coumarin based polymers: synthesis and applications; A. Joy, M.V.S.N. Maddipatla; US 9,663,614; issued: May 30, 2017
  5. Biodegradable polymers with pendant functional groups attached through amide bonds; A. Joy, S. Gokhale, Y. Xu; US 9,593,201; issued: March 14, 2017
  6. Substituted phenacyl molecules and photoresponsive polymers; A. Joy, S. Sun; US 9,353,214; issued: May 31, 2016

Peer Reviewed Publications

Why this is cool: This paper shows that poor antimicrobial polymers don’t have to be useless and can be effective antibiofilm agents. 

 

Jain, T.; Baker, H. B.; Gipsov, A.; Fisher, J. P.; Joy, A.; Kaplan, D. S.; Isayeva, I. Impact of cell density on the bioprinting of gelatin methacrylate (GelMA) bioinks. Bioprinting 2021, e00131.

Nun, N.; Cruz, M.; Jain, T.; Tseng, Y.-M.; Menefee, J.; Jatana, S.; Patil, P. S.; Leipzig, N. D.; McDonald, C.; Maytin, E.; and Joy, A. Thread Size and Polymer Composition of 3D Printed and Electrospun Wound Dressings Affect Wound Healing Outcomes in an Excisional Wound Rat Model. Biomacromolecules 2020, 21, 4030.

Liu, X.; Jain, T.; Liu, X.; Joy, A. Structural Insight into the Viscoelastic Behaviour of Elastomeric Polyesters: Effect of the Nature of Fatty Acid Side Chains and the Degree of Unsaturation. Polym. Chem. 2020, 11, 5216-5224.

Kundu, M.; Morris, D. L.; Cruz, M. A.; Miyoshi, T.; Leeper, T. C.; Joy, A. Elucidating the Molecular Interactions of Encapsulated Doxorubicin Within a Nonionic, Thermoresponsive Polyester Coacervate. ACS Appl. Bio. Mater. 2020, 3, 4626.

Narayanan, A.; Menefee, J. R.; Liu, Q.; Dhinojwala, A.; Joy, A. Lower Critical Solution Temperature-Driven Self-Coacervation of Nonionic Polyester Underwater Adhesives. ACS Nano 2020, 14, 8359.

Narayanan, A.; Xu, Y.; Dhinojwala, A.; Joy, A. Advances in Photoreactive Tissue Adhesives Derived from Natural Polymers. ChemEngineering 2020, 4, 32

Liu, Q.; Jain, T.; Peng, C.; Peng, F.; Narayanan, A.; Joy, A. Introduction of Hydrogen Bonds Improves the Shape Fidelity of Viscoelastic 3D Printed Scaffolds While Maintaining Their Low Temperature Printability. Macromolecules 2020, 53, 3690.

Nun, N.; Xu, Y.; Joy, A. Pendant Functionalized Polyester Nanofibers with Dual Cargo Release. ACS Appl. Bio Mater. 2019, 2, 4856.

Mankoci, S.; Ewig, J.; Dalai, P.; Sahai, N.; Barton, H. A.; Joy, A. Bacterial Membrane Selective Antimicrobial Peptide-Mimetic Polyurethanes: Structure-Property Correlations and Mechanisms of Action. Biomacromolecules 2019, 20, 4096

Jain, T.; Clay, W.; Tseng, Y.-M.; Vishwakarma, A.; Narayanan, A.; Ortiz, D.; Liu, Q.; Joy, A. Role of pendant side-chain length in determining 3D printability. Polym. Chem. 2019, 10, 5543.

Narayanan, A.; Kaur, S.; Peng, C.; Debnath, D.; Mishra, K.; Liu, Q.; Dhinojwala, A.; Joy, A. Viscosity Attunes the Adhesion of Bioinspired Low Modulus Polyesters to Wet Tissues. Biomacromolecules 2019, 20, 2577.

Liu, Q.; Yuan, S.; Guo, Y.; Narayanan, A.; Peng, C.; Wang, S.; Miyoshi, T.; Joy, A. Modulating the Crystallinity, Mechanical Properties, and Degradability of Poly (𝛆-caprolactone) Derived Polyesters by Statistical and Alternating Copolymerization. Polym. Chem. 2019, 10, 2579.

Peng, C.; Vishwakarma, A.; Mankoci, S.; Barton, H. A.; Joy, A. Structure-Activity Study of Antibacterial Poly(Ester Urethane)s with Uniform Distribution of Hydrophobic and Cationic Groups. Biomacromolecules 2019, 20, 1675.

Peng, C.; Zhang, T.; Ortiz-Ortiz, D.; Vishwakarma, A.; Barton, H.; Joy, A. Modification of Narrow-Spectrum Peptidomimetic Polyurethanes with Fatty Acid Chains Confers Broad-Spectrum Antibacterial Activity, Polym. Int. 2019, 68. 1255.

Jain, T.; Saylor, D. M.; Piard, C. M. Liu, Q.; Patel, V.; Kaushal, R.; Choi, J.-W.; Fisher, J. P.; Isayeva, I.; Joy, A. The effect of dexamethasone on room temperature 3D printing, rheology, and degradation of a low modulus polyester for soft tissue engineering, ACS Biomater. Sci. Eng. 2019, 5, 846.

Liu, Q.; Wang, C.; Guo, Y.; Peng,C.; Narayanan, A.; Kaur, S.; Xu, Y.; Weiss, R. A.; Joy, A. Opposing Effects of Side-Chain Flexibility and Hydrogen Bonding on the Thermal, Mechanical and Rheological Properties of Supramolecularly Crosslinked Polyesters, Macromolecules 2018, 51, 9294.

Kaur, S.; Narayanan, A.; Dalvi, S.; Liu, Q.; Joy, A.; Dhinojwala, A. Direct Observation of the Interplay of Catechol Binding and Polymer Hydrophobicity in a Mussel-Inspired Elastomer, ACS Cent. Sci. 2018, 4, 1420.

Guo, Y.; Liu, Q.; Peng, C.; Wang, E. Joy, A.; Cakmak, M. Colloid silica nanoparticles trapped morphology of polymer blends during solvent evaporation, Eur. Polym. J. 2018, 107, 164.

Dhopatkar, N.; Anim-Danso, E.; Peng, C.; Singla, S.; Liu, X.; Joy, A.; Dhinojwala, A. Reorganization of an Amphiphilic Glassy Polymer Surface in Contact with Water Probed by Contact Angle and Sum Frequency Generation Spectroscopy, Macromolecules, 2018, 51, 5114.

Govindarajan, S. R.; Jain, T.; Choi, J.-W.; Joy, A.; Isayeva, I.; Vorvolakos, K. A. Hydrophilic coumarin-based polyester for ambient-temperature initiator-free 3D printing: Chemistry, rheology and interface formation, Polymer 2018, 152, 9-17

Peng, C.; Vishwakarma, A.; Li, Z.; Miyoshi, T.; Barton, H. A.; Joy, A. Modification of a Conventional Polyurethane Composition Provides Significant Anti-biofilm Activity Against Escherichia coli. Polym. Chem. 2018, 9, 3195.

Kadry, H.; Al-Hilal, T. A.; Keshavarz, A.; Alam, F.; Xu, C.; Joy, A.; Ahsan, F. Multi-Purposable Filaments of HPMC for 3D Printing of Medications with Tailored Drug Release and Timed-Absorption. Int. J. Pharm. 2018, 544, 285-296.

Cruz, M. A.; Morris, D. L.; Swanson, J. P.; Kundu, M.; Mankoci, S. G.; Leeper, T. C.; Joy, A. Efficient Protein Encapsulation within Thermoresponsive Coacervate-Forming Biodegradable Polyesters. ACS Macro Lett. 2018, 7, 477.

Swanson, J. P.; Cruz, M. A.; Monteleone, L. R.; Martinez, M. R.; Costanzo, P. J.; Joy, A. The Effect of Pendant Group Structure on the Thermoresponsive Properties of N-Substituted Polyesters. Polym. Chem. 2017, 8, 7195.

Xie, Y.; Peng, C.; Gao, Y.; Liu, X.; Liu, T.; Joy, A. Mannose-Based Graft Polyesters with Tunable Binding Affinity to Concanavalin A. J. Polym. Sci., 2017, 55, 3908. 

Xu, Y.; Liu, Q.; Narayanan, A.; Jain, D.; Dhinojwala, A.; Joy, A. Mussel-Inspired Polyesters with Aliphatic Pendant Groups Demonstrate the Importance of Hydrophobicity in Underwater Adhesion. Adv. Mater. Interfaces. 2017, 1700506 (1-6)

Mankoci, S.; Kaiser, R.; Sahai, N.; Barton, H. A.; Joy, A. Bactericidal Peptidomimetic Polyurethanes with Remarkable Selectivity against Escherichia coli. ACS Biomater. Sci. Eng. 2017, 3, 2588.

Alexander, N. E.; Swanson, J. P.; Joy, A.; Wesdemiotis, C. Sequences of cyclic polysester copolymers using ion mobility tandem mass spectrometry. Int. J. Mass Spectrom. 2018, 429, 151-157

Peng, C.; Joy, A. Alternating and Random-Sequence Polyesters with Distinct Physical Properties. Polym. Chem. 2017, 8, 2397

Wehrung, D.; Chamsaz, E. A.; Andrews, J. H.; Joy, A.; Oyewumi, M. O. Engineering Alkoxyphenacyl-Polycarbonate Nanoparticles for Potential Application in Near-Infrared Light-Modulated Drug Delivery via Photon Up-Conversion Process. J. Nanosci. Nanotechnol. 2017, 17, 4867

Lin, P.; Xu, Q.; Cheng, S.; Li, X.; Zhao, Z.; Sun, S.; Peng, C.; Joy, A.; Wang, S.-Q. Effects of Molecular Weight Reduction on Brittle−Ductile Transition and Elastic Yielding Due to Noninvasive γ Irradiation on Polymer Glasses. Macromolecules 2017, 50, 2447

Chamsaz, E. A.; Mankoci, S.; Barton, H. A.; Joy, A.  Non-toxic Cationic Coumarin Polyester Coatings Prevent Pseudomonas aeruginosa Biofilm Formation    ACS Appl. Mater. Interfaces 2017, 9, 6704

Manickavasagam, D., Wehrung, D., Chamsaz, E. A., Sanders, M., Bouhenni, R. Crish, S. D., Joy, A., Oyewumi, M. O. Assessment of alkoxylphenacyl-based polycarbonates as a potential platform for controlled delivery of a model anti-glaucoma drug; Eur. J. Pharm. Biopharm. 2016, 107, 56

D., Liu, Q., Jain, T., Joy, A., Brooks, A. E.; An Osteoconductive Antibiotic Bone Eluting Putty with a Custom Polymer Matrix; Polymers 2016, 8, 247

Swanson, J.; Martinez,M.; Cruz, M.; Mankoci, S.; Costanza, P.; Joy, A., A Coacervate-forming Biodegradable Polyester with Elevated LCST based on Bis-(2-methoxyethyl)amine;  Polym. Chem., 2016, 7, 4693

Govindrajan, S.; Xu, Y.; Swanson,J.; Jain, T.; Lu, Y.; Choi, J,W.; Joy,A., A Solvent and Initiator Free, Low Modulus, Degradable Polyester Platform with Modular Functionality for Ambient Temperature 3D Printing; Macromolecules, 2016, 49, 2429

Paulmurugan, R.; Bhethanabotla, R.; Mishra, K.; Devulapally, R.; Foygel, K.; Sekar, T. V.; Ananta, J. S.; Massoud, T. F.; Joy, A., Folate receptor targeted polymeric micellar nanocarriers for delivery of orlistat as a repurposed drug against triple negative breast cancer. Mol. Cancer Ther. 2016, 15, 221

Swanson, J. P., Monteleone, L. R., Haso, F., Costanzo, P. J., Liu, T., Joy, A; A library of thermoresponsive, coacervate-forming biodegradable polyesters; Macromolecules, 2015, 48, 3834

C. Peng, A. Joy; Self-emulsion polymerization of Baylis-Hillman-derived α-hydroxymethyl-substituted acrylates: J. Polym. Sci. Part A: Polym. Chem.2015, 53, 1743

K. Mishra, A.Joy; Dual functionalized telechelic block copolymers with reproducible block sizes prepared by microwave assisted RAFT polymerization; Polymer, 2015, 66, 110

Zhou, J., Mishra, K. Bhagat, V., Joy, A., Becker, M. L.; Thermoresponsive dual emission nanosensor based on quantum dots and dye labeled poly (N-isopropylacrylamide) Polym. Chem. 2015, 6, 2813

Lee, J., Maddipatla, M. V. S. N., Joy, A.*, Vogt, B. D.*; Kinetics of UV Irradiation Induced Chain Scission and Cross-Linking of Coumarin-Containing Polyester Ultrathin Films; Macromolecules 2014, 47, 2891

Wehrung, D., Chamsaz, E. A., Joy, A., Oyewumi, M. O.; Formulation and photoirradiation parameters that influenced photoresponsive drug delivery using alkoxylphenacyl-based polycarbonates;  Eur. J. Pharm. Biopharm. 2014, 88, 962.

C. Peng, A. Joy; Baylis-Hillman reaction as a versatile platform for the synthesis of diverse functionalized polymers by chain and step polymerization; Macromolecules, 2014, 47, 1258

McCormick, A. M.; Maddipatla, M. V. S. N.; Shi, S.; Chamsaz, E. A.; Yokoyama, H.; Joy, A.; Leipzig, N. D; Micropatterned coumarin polyester thin films direct neurite orientation; ACS Appl. Mater. Inter., 2014, 22, 19655

E.A. Chamsaz, S. Sun, M.V.S.N. Maddipatla, A. Joy; Photoresonsive polyesters by incorporation of alkoxyphenacyl or coumarin chromophores along the backbone; Photochem. Photobiol. Sci. 2014, 13, 412

S. Gokhale, Y. Xu, A. Joy; A library of multifunctional polyesters with ‘peptide-like’ pendant functional groups; Biomacromolecules, 2013, 14, 2489

M. V. S. N. Maddipatla, D. Wehrung, C. Tang, W. Fan, M. O. Oyewumi, T. Miyoshi, A. Joy; Photoresponsive coumarin polyesters that exhibit cross-linking and chain scission properties; Macromolecules, 2013, 46, 5133

D. Wehrung, S. Sun, E. A. Chamsaz, A. Joy, M. O. Oyewumi; Biocompatibility and in-vivo tolerability of a new class of photoresponsive alkoxyphenacyl-based polycarbonates; J. Pharm. Sci. 2013, 102, 1650

S. Sun, E. A. Chamsaz, A. Joy; Photoinduced polymer chain scission of alkoxyphenacyl based polycarbonates; ACS Macro Letters, 2012, 1, 1184

P. M. Kou, N. Pallassana, R. Bowden, B. Cunningham, A. Joy, J. Kohn, J. E. Babansee; Predicting biomaterial property-dendritic cell phenotype relationships form the multivariate analysis of responses to polymethacrylates; Biomaterials 2012, 33, 1699

J. Ghosh, D. Y. Lewitus, P. Chandra, A. Joy, J. Bushman, D. Knight, J. Kohn; Computational modeling of in vitro biological responses on polymethacrylate surfaces; Polymer, 2011, 52, 2650

A. Joy, D. Cohen, A. Luk, E. Anim-Danso, C. Chen, J. Kohn; Control of surface chemistry, substrate stiffness and cell function in a novel terpolymer methacrylate library; Langmuir 2011, 27, 1891

H.-J. Sung, A. Luk, N.S. Murthy, Er Liu, M. Jois, A. Joy, J. Bushman, P.V. Moghe, J. Kohn; Poly(ethylene glycol) as a sensitive regulator of cell survival fate on polymeric biomaterials: The interplay of cell adhesion and pro-oxidant signaling mechanisms; Soft Matter 2010, 6, 5196